noon
Ever been interested in a career in journalism? You don't have to study journalism to be successful in this career, says Frauke Böger, the editor of German online news magazine Der Spiegel. On Monday, April 14, at 12 PM on ZOOM, Böger will speak to you about her career path and how studying languages and history helped her become chief editor of this leading German online news magazine. She will be joined by Camila Mortensen, chief editor, and owner of the Eugene Weekly. Mortensen will also discuss her career path and what's important for students in German and Scandinavian to be successful in a journalism and writing career. Both Mortenson and Böger will speak approximately 30 minutes each. There will be a Q&A following their presentations. If you are interested in joining, please send an email to matvogel@uoregon.edu. The event is free and open to the public, so please invite others to join.
2:00 p.m.
Department of Chemistry and Biochemistry Physical Chemistry Seminar Series
Professor Omar Valsson, University of North Texas Hosted by: Dhiman Ray
From Stability to Dissociation: Elucidating Dissociation Kinetics of Protein-Protein Complexes via Atomistic Simulations
Protein-protein interactions (PPI) are ubiquitous in biological processes. Their study has significant implications for drug discovery as PPIs are important pharmacological targets for small molecules and important in various therapeutic modalities, such as targeted protein degradation and antibodies. Therefore, understanding the stability and dissociation of protein-protein complexes is of great fundamental and practical interest. In particular, the unbinding/residence times of ligands and peptide therapeutics from their target proteins (i.e., k_off, the dissociation rate constant) is a vital parameter as it is known that the dissociation kinetics are directly correlated to the pharmacological activity and efficacy of drug molecules [1]. Therefore, obtaining the dissociation kinetics from atomistic simulations has been a fundamental task in the atomistic modeling field [2]. Here, enhanced sampling methods are needed as the unbinding/dissociation event is a rare event on the simulation time scale [3]. While considerable effort has been made to obtain the unbinding/residence times in protein-ligand complexes, there have been much more limited applications towards the more challenging case of protein-protein dissociation kinetics [2].
In this talk, I will present my group’s research program that is focused on elucidating the dissociation kinetics of protein-protein complexes using atomistic simulations augmented with enhanced sampling methods, such as infrequent metadynamics [3]. I will present our results for various challenging protein-protein system, including MDM2-p53 and barnase-barstar. I will discuss how the protein model (i.e., force field) can affect the results. I will discuss the future perspective of our research program, including investigating how different stabilizing molecules effect the stability and dissociation kinetics of protein-protein complexes. Furthermore, I will discuss applications towards understanding targeted protein degradation.
References[1] R. A. Copeland, “The drug–target residence time model: a 10-year retrospective”, Nat. Rev. Drug Discov., 15, 87–95 (2016).[2] J. Wang, H. N. Do, K. Koirala, and Y. Miao, “Predicting Biomolecular Binding Kinetics: A Review”, J. Chem. Theory Comput., 19, 2135-2148 (2023).[3] J. Hénin, T. Lelièvre, M. R. Shirts, O. Valsson, and L. Delemotte, “Enhanced Sampling Methods for Molecular Dynamics Simulation”, Living J. Comput. Mol. Sci. 4, (2022).
3:00–4:30 p.m.
Native American and Indigenous Research Colloquium
Students from the UO School for Architecture and Environment have been working with NILI (Northwest Indigenous Language Institute) and Native American and Indigenous Studies on a project focused on Native Language learning, preservation, and revitalization. This project has two design stages: first, the renovation of the current infrastructure of the NILI house based on a real demand; second, a speculative proposal with the intention to expand the preservation and revitalization of the Native Languages to a broader audience.
Join students as they share their proposals imagining how languages can be expressed and celebrated in diverse and inclusive ways, creating a dynamic cultural space for the community.
7:00 p.m.
Please join us for the April pub lecture hosted by the Department of History and the Lane County Historical Society. Assistant Professor Hannah Cutting-Jones will discuss "Back to Your Roots: Nutritional Advice to the Cook Islands, 1850-1975."
Free and open to everyone!
The UO Department of History and the Lane County Historical Society present a series of talks with scholars about history, from the local to the global. Join us for stories, food, and conversation in a casual setting!
10:00 a.m.
Please join us Tuesday mornings for a free cup of coffee, pastries, and conversation with your history department community! We’re excited to continue this tradition for our history undergraduate and graduate students, faculty, and staff. We hope to see you there!
noon
Enjoy stress-free time together with disabled and neurodivergent graduate students from across campus. Share experiences, exchange resources, or consult with a GE from the Accessible Education Center.
noon
New Faculty Roundtable and Lunch
The Center for Latino/a and Latin American Studies (CLLAS) is pleased to to announce a dynamic roundtable discussion featuring new UO faculty members across various departments who specialize in Latino/a and Latin American studies! We are excited to welcome:
Naomi Sussman – Assistant Professor, History Research Interests: Indigenous history, borderlands history, sovereignty, citizenship, race, history of migration
Isabel García Valdivia – Assistant Professor, Sociology Research Interests: [Im]migration, Race and Ethnicity, Social Stratification, and Life course/Aging
Guillem Belmar Viernes – Assistant Professor, Linguistics Research Interests: Language revitalization, language maintenance, language rights, minoritized languages, endangered languages, language documentation, minority multilingualism, Minoritized Languages and (Social Media), Minoritized Language Translation, and more
Please join us in welcoming these faculty members to UO and learning about their research, coursework, and the valuable contributions they will make in educating students about Latinx and Latin American issues across various disciplines.
Lunch will be provided. We hope to see you there!
2:00–3:00 p.m.
Are you looking for ways to really stand out as a candidate? Come learn about the basics of resume writing and have the opportunity to ask questions on formatting, structure, and bring your own resume for tailoring and much more! Questions are welcomed and encouraged!
Workshop is IN-PERSON, in Tykeson Hall-Garden Level 50P (aka University Career Center Conference Room) This workshop is hosted by the University Career Center's Career Readiness Coaching team!
This event is part of the 2025 Spring Career Readiness Week sponsored by the University Career Center, Enterprise Mobility, and Sherwin Williams. To learn more about all of the week's events visit http://career.uoregon.edu/events
4:00–6:30 p.m.
The United States has the largest tech market in the world (1/3 of a $5 TRILLION industry!) and overall employment in computer and information technology occupations is projected to grow much faster than the average for all occupations in the next decade! (learn more) The future of the technology industry is so much more than just artificial intelligence and social media platforms. About 377,500 competitive openings are projected each year in the U.S.A. in these highly skilled roles—are you up for the challenge?
Join us for a special industry-connection night dedicated to helping YOU get career ready for your future in Tech. Come to either or both events—Learn something new and meet employers and alumni you can add to your network!
4-5pm Industry Insights Panel
Hear from alumni, industry leaders, and experts about their career journeys, the future of the industry, and how you can be developing the career readiness skills, technical skills, and connections today to thrive in your future in Tech.
PANELISTS
Selva Haidar:Area Manager for AmazonMichelle Regotti UO’20 MS, Applied Physics (Semiconductors), Metrology Process Engineer for HP
D. Blair Elzinga, Director of Software Development for Oregon Community Credit Union
5:15-6:30pm Connect with Tech Employers
Grab a snack & rotate through casual small group chats with alumni, professionals, and employers to learn more about their companies, career paths, and get advice about how to find career-building opportunities and connections for your future in Tech.
COMPANIES
Allmax Software Amazon EBIO HP Lane County Government Nulia Oregon Community Credit Union Palo Alto Software Pipeworks SentinelOne SheerID WellBeyond and more!Both events are open to all majors and academic years. Snacks provided. Casual Dress. No RSVP is required. Bring your friends!
Sponsored by the University Career Center and the School of Computer and Data Sciences as part of Spring Career Readiness Week 2025.
10:00–11:00 a.m.
Creating citations and bibliographies can be difficult, and so can keeping track of all the reading that you’ll do over the course of a class, a term, and your academic career.
Join UO Libraries for a one-hour workshop where you’ll learn to navigate Zotero, a free, open-source citation management tool designed to simplify your research process.
In this session, we will introduce you to Zotero’s features, showing you how to collect, organize, cite, and share your research effortlessly. You’ll learn how to create bibliographies and in-text citations in popular styles such as MLA, APA, and Chicago, all while developing strategies to effectively utilize Zotero in your writing.
Join us in the PSC Visualization Lab and transform the way you manage your research!
This workshop is free and open to the UO community.